BiEstro-Care is a combination of two estrogens for peri-menopause and menopause solutions in an 80/20 ratio. Each full press of the pump provides approximately 1 mg of natural Estriol USP and 0.25 mg of natural Estradiol USP. Formulated to contain 24 mg of estriol and 6 mg of estradiol per ounce.Free Of Paraben and animal testing. Disclaimer These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.